Advances in Stem Cell Biology
Ref. 96016
With this MOOC you will learn about the characteristics and properties of stem cells, as well as the latest discoveries in the field.
- Duration: 9 weeks
- Effort: 24 hours
- Pace: ~2h45/week
- Languages: English and french
What you will learn
At the end of this course, you will be able to:
- Summarize the general concepts in stem cell biology
- Describe how tissue specific stem cells participate in organogenesis
- Explain how to derive pluripotent stem cells
- Define how organoids can help to understand development biology
- Discuss stem cell applications for therapeutic purposes
Description
Stem cells have the spectacular ability to restore the function of damaged tissues, providing major opportunities for fundamental studies on organogenesis, regeneration, diseases, and ageing. In spite of intense research in this field, many unanswered questions remain regarding stem cell regulation and function.
The Advances in Stem Cell Biology MOOC was created to provide an overview of stem cell biology, the properties of stem cells and their potential in directing organogenesis and regeneration in different organisms, and how they can be exploited for therapeutic purposes.
During this MOOC you will learn about the characteristics and properties of stem cells, along with the latest discoveries in the field from general concepts to different categories of stem cells, and how they participate in organogenesis in the organism - and in vitro.
Format
This MOOC is organized in 5 chapters, each module is composed of 5 to 10 sessions. In each session, you will find a 8-10-minute video and a multiple choice test to help you check your understanding. The videos are in English subtitled in French and in English.
With the participation of :
Shahragim Tajbakhsh, François Schweisguth, Marc Van de Wetering, Allison Bardin, Ana Cumano, Philippe Herbomel, Pierre-Marie Lledo, Matthias Lutolf, Sigolène Meilhac, Laurence Daheron, Kat Hadjantonakis, Jenny Nichols, Alfonso Martinez Arias, Emmanuelle Rial-Sebbag.
This MOOC was realized with the support of the LaBex REVIVE.
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Prerequisites
We recommend a good scientific background (such as a bachelor of life science)
Assessment and certification
To follow this course, you have the choice between two formulas. The DISCOVERY path gives you access to videos, quizzes and exchanges in the forum. Additionnaly, the QUALIFYING path gives you access to a qualifying exam.
- Discovery path
If you opt for this path, you will have access to the videos, the quizzes and the exchanges in the forum. For this path, no certificate will be delivered. The registration is free.
- Qualifying path
In addition to the activities offered in the DISCOVERY path, the QUALIFYING formula will allow you to obtain a certificate in the form of a "certificate". To do this, you will have to take a exam, monitored remotely, lasting 1 hour, consisting of 30 multiple choice questions (MCQ) and obtaining 18 correct answers.
The registration fee for the qualifying course is 150€.
Course plan
- C1-1 What are Stem cells / Shahragim Tajbakhsh - Institut Pasteur, FR
C1-2 What defines the fate of stem cells ? / Shahragim Tajbakhsh - Institut Pasteur, FR
C1-3 Introduction to asymmetric cell division / Francois Schweisguth - Institut Pasteur, FR
C1-4 Asymmetric cell division: the cellular and molecular processes
- C2-1 Intestinal stem cells / Marc Van De Wertering - Princess Maxima Center for Pediatric Oncology, NL
C2-2 Drosophila Intestinal Stem Cells / Allison Bardin - Institut Curie, FR
C2-3 Introduction to Hematopoietic stem cells / Ana Cumano - Institut Pasteur, FR
C2-4 Origins of hematopoietic stem cells / Ana Cumano - Institut Pasteur, FR
C2-5 Tracking the journey of hematopoietic stem cells in live zebrafish embryos / Philippe Herbomel - Institut Pasteur, FR
C2-6 Neural Stem cells / Pierre-Marie Lledo - Institut Pasteur, FR
C2-7 Skeletal muscle identity / Shahragim Tajbakhsh - Institut Pasteur, FR
C2-8 Skeletal muscle stem cell properties and ageing / Shahragim Tajbakhsh - Institut Pasteur, FR
C2-9 Deconstructing and reconstructing a satellite cell niche
C2-10 Heart regeneration / Sigolène Meilhac - Institut Pasteur, Institut Imagine, FR
- C3-1 Human pluripotent stem cell derivation / Laurence Daheron - Harvard Stem Cell Institute, USA
C3-2 What are the most common methods to generate iPSCs ? / Laurence Daheron- Harvard Stem Cell Institute, USA
C3-3 Specification and segregation of embryonic vs. extra-embryonic stem cells / Kat Hadjantonakis - Sloan Kettering Institute, USA
C3-4 Differentiation of ICM cells: the underlying mechanisms / Kat Hadjantonakis - Sloan Kettering Institute, USA
C3-5 Derivation of mouse embryonic stem cells / Jenny Nichols - Cambridge Stem Cell Institute, UK
C3-6 Derivation of human embryonic stem cells / Jenny Nichols - Cambridge Stem Cell Institute, UK
- C4-1 Using ES cells to understand how cells build organisms / Alfonso Martinez Arias - University of Cambridge, UK
C4-2 Self-organization of embryonic organoids / Alfonso Martinez Arias - University of Cambridge, UK
- C5-1 Intestinal cancer stem cells / Marc Van De Wertering - Princess Maxima Center for Pediatric Oncology, NL
C5-2 The bioethics of stem cell research and therapy / Emmanuelle Rial-Sebag - Inserm, FR
Course team
Shahragim Ttajbakhsh
Categories
Prof. Shahragim Tajbakhsh – Stem Cells and Development team at Institut Pasteur.
Marina CAILLET
Categories
Doctor in virology, Marina is program manager at the Institut Pasteur. She is your community manager for this MOOC
Organizations
License
License for the course content
Attribution-NonCommercial-NoDerivatives
You are free to:
- Share — copy and redistribute the material in any medium or format
Under the following terms:
- Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- NonCommercial — You may not use the material for commercial purposes.
- NoDerivatives — If you remix, transform, or build upon the material, you may not distribute the modified material.
License for the content created by course participants
Attribution-NonCommercial-NoDerivatives
You are free to:
- Share — copy and redistribute the material in any medium or format
Under the following terms:
- Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- NonCommercial — You may not use the material for commercial purposes.
- NoDerivatives — If you remix, transform, or build upon the material, you may not distribute the modified material.