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  • Basics of Nuclear Magnetic Resonance

Basics of Nuclear Magnetic Resonance

Ref. 54009
CategoryPhysics and chemistry
NMR : A powerful technique to probe the structure and dynamics of molecules
  • Duration: 5 weeks
  • Effort: 20 hours
  • Pace: ~4 hours/week
  • Languages: English

What you will learn

At the end of this course, you will be able to:

  • to understand the principles of nuclear magnetic resonance (NMR) and the basic liquid-state NMR experiments;
  • to interpret one- and two-dimensional (1D and 2D) 1H and 13C NMR spectra of small organic molecules;
  • to determine the structure and purity of small organic molecules in solution using NMR spectroscopy.   

Description

The NMR phenomenon is currently exploited for many purposes, including medical imaging using the MRI technique as well as the characterization of the structure and the dynamics of matter at molecular scale by NMR spectroscopy, which is a key tool in chemistry, structural biology, pharmacology and material sciences.

"Basics of Nuclear Magnetic Resonance" is the first course of a comprehensive three-part online learning programme on NMR.
It aims at providing students and professionals the basic knowledge about NMR. The MOOC sets out the principles of NMR in solutions as well as one- and two-dimensional 1H and 13C NMR experiments and their application to small organic molecules in solution.

This course is intended for undergraduate and graduate students as well as educators and professionals who need to gain proficiency as routine users of NMR spectroscopy of organic molecules in solution.

Format

During the five weeks of this MOOC you will learn the basic principles of NMR spectroscopy and its use to determine the structure of organic molecules, through video lectures and online exercices such as case studies and quizzes, as well as discussions with other participants and professors through the discussion forum.
This MOOC is taught in English.
Subtitles in simplified Chinese and Japanese are also provided.

Prerequisites

Students should have a background in basic chemistry, including:
 - the atoms, the elements and the periodic table;
 - the structure of organic molecules (functional groups, electronic effects, stereochemistry);
as well as some basic knowledge in physics

Assessment and certification

The acquired knowledge will be tested through practice and graded quizzes, case studies as well as a final exam.
Your final grade is a weighted average of your grades obtained for the graded quizzes, case studies and the final exam.
You will earn an  course completion badge for this MOOC provided your final grade is above 65%.

Course plan

  • Week 1: Importance of NMR and the basic principles of NMR spectroscopy.
  • Week 2: NMR experiment and 1H NMR of organic molecules in solution.
  • Week 3: Probing covalent bonds and connectivities in organic molecules via J-couplings.
  • Week 4: 13C NMR of organic molecules in solution.
  • Week 5: 2D NMR of organic molecules in solution.

Course team

Olivier Lafon

Categories

Olivier Lafon is professor at the University of Lille and honorary member of Institut Universitaire de France (IUF). The focus of his research is to push the frontiers of solid-state NMR spectroscopy in order to gain unique insights into the structure-property relationships of materials used in the field of energy, bioeconomy and health. His current research interests notably include the development of novel solid-state NMR methods, especially at high magnetic fields, for quadrupolar nuclei or using Dynamic Nuclear Polarization (DNP) as well as their application for the characterization of materials, including battery materials, quantum dots, photovoltaic materials, heterogeneous catalysts and porous materials. Olivier Lafon received B.Sc. in physical chemistry from Ecole Normale Supérieure de Lyon. He passed the agrégation in physical sciences. He received MS and PhD from the University of Paris South. He was awarded the Magnetic Resonance in Chemistry Award for Young Scientists by the Euromar scientific committee. He is the director of Lille high-field NMR facility, which hosts 1.2 GHz NMR spectrometer for the study of liquids and solids and belongs to INFRANALYTICS research infrastructure. He also coordinates the French network of research infrastructure in physical sciences and engineering (IR SMI). He is also a member of the editorial board of Solid-State Nuclear Magnetic Resonance.

Cedric Lion

Categories

Cedric Lion is associate professor at the University of Lille specializing in bioorganic chemistry, chemical biology and bioimaging. His research topics at the Institute for Structural and Chemical Glycomics (UMR 8576 – UGSF) focus on developing chemical tools and methods for the study of glycosylation pathways in physiological and pathological conditions with bioanalytical techniques. He has a special interest in fluorescence spectroscopy and NMR spectroscopy, and the development of labelling methodologies for bioimaging in human, bacterial and plant models exploiting bioorthogonal chemistry. He is the coordinator and director of the Erasmus Mundus Joint Master “Advanced Spectroscopy in Chemistry” offered by a network of five universities: Lille (France, coordinating institution), Helsinki (Finland), Leipzig (Germany), Bologna (Italy), Krakow (Poland) funded by the European Education and Culture Executive Agency of the European Union.

Organizations

University of Lille

NMR Learning programme

This MOOC is part of the NMR learning programme which aims at understanding the different aspects of this technique, which is a key tool in chemistry, structural biology, material sciences, food sciences and medicine.

This comprehensive online learning programme is composed of three parts :

Basics of Nuclear Magnetic Resonance

To understand the principles of nuclear magnetic resonance (NMR) and to interpret 1D and 2D 1H and 13C NMR spectra of small organic molecules

Advanced NMR

To learn how liquid-state NMR experiments work and can be applied to analyze biological macromolecules and mixtures of metabolites, but also to acquire MRI images

Solid-state NMR

To discover solid-state NMR experiments and how they can be applied to investigate the atomic-level structure and dynamics of solids

Acknowledgements

Dr. Ming Shen, associate professor at East China Normal University, P. R. China, and Dr. Akiko Sasaki, researcher at Bruker BioSpin, Japan are acknowledged for the translation of the subtitles into simplified Chinese and Japanese, respectively.

License

License for the course content

Attribution-NonCommercial-NoDerivatives

You are free to:

  • Share — copy and redistribute the material in any medium or format

Under the following terms:

  • Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
  • NonCommercial — You may not use the material for commercial purposes.
  • NoDerivatives — If you remix, transform, or build upon the material, you may not distribute the modified material.

License for the content created by course participants

Attribution-NonCommercial-NoDerivatives

You are free to:

  • Share — copy and redistribute the material in any medium or format

Under the following terms:

  • Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
  • NonCommercial — You may not use the material for commercial purposes.
  • NoDerivatives — If you remix, transform, or build upon the material, you may not distribute the modified material.
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